Researchers at Florida International University Have Reported New Data on Organic Chemistry (Emission Tuning of Fluorescent Kinase Inhibitors:...

Life Science Weekly |

Researchers at Florida International University Have Reported New Data on Organic Chemistry (Emission Tuning of Fluorescent Kinase Inhibitors: Conjugation Length and Substituent Effects) By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Organic Chemistry have been published. According to news originating from Miami, Florida, by NewsRx correspondents, research stated, "Fluorescent N-phenyl-4-aminoquinazoline probes targeting the ATP-binding pocket of the ERBB family of receptor tyrosine kinases are reported. Extension of the aromatic quinazoline core with fluorophore 'arms' through substitution at the 6- position of the quinazoline core with phenyl, styryl, and phenylbutadienyl moieties was predicted by means of TD-DFT calculations to produce probes with tunable photoexcitation energies and excited states possessing charge-transfer character." Our news journalists obtained a quote from the research from Florida International University, "Optical spectroscopy identified several synthesized probes that are nonemissive in aqueous solutions and exhibit emission enhancements in solvents of low polarity, suggesting good performance as turn-on fluorophores. Ligand-induced ERBB2 phosphorylation assays demonstrate that despite chemical modification to the quinazoline core these probes still function as ERBB2 inhibitors in MCF7 cells." According to the news editors, the research concluded: "Two probes were found to exhibit ERBB2-induced fluorescence, demonstrating the utility of these probes as turn-on, fluoroescent kinase inhibitors." For more information on this research see: Emission Tuning of Fluorescent Kinase Inhibitors: Conjugation Length and Substituent Effects. Journal of Organic Chemistry, 2014;79(11):4940-4947. Journal of Organic Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Organic Chemistry - www.pubs.acs.org/journal/joceah) The news correspondents report that additional information may be obtained from J. Dhuguru, Florida International University, Dept. of Chem & Biochem, Miami, FL 33199, United States. Additional authors for this research include W.J. Liu, W.G. Gonzalez, W.M. Babinchak, J. Miksovska, R. Landgraf and J.N. Wilson (see also Organic Chemistry). Keywords for this news article include: Miami, Kinase, Florida, United States, Organic Chemistry, Enzymes and Coenzymes, North and Central America Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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