By a News Reporter-Staff News Editor at Life Science Weekly — From Washington, D.C., NewsRx journalists report that a patent application by the inventors LEE, Soo-Min (Seoul, KR); LEE, Sooheun (Suwon, KR); RYU, Keun-Ho (Seoul, KR); LEE, Bong-Yong (Seoul, KR); KIM, Jae-Sun (Suwon, US); OH, Jung-Hoon (Seoul, KR); JEON, Ye-Ji (Suwon, US), filed on March 3, 2014, was made available online on July 3, 2014 (see also Sk Chemicals Co., Ltd.).
The patent’s assignee is Sk Chemicals Co., Ltd.
News editors obtained the following quote from the background information supplied by the inventors: “Skin tends to be more susceptible to wrinkles than any other tissue because of frequent contact with various external stimuli. Particularly, facial skin is directly exposed to environmental factors such as sunlight, dry air and pollutants, and it begins to wrinkle earlier than other skin tissues.
“The most characteristic change arising from the aging of skin tissues takes place in the skin matrix. Aging reduces the ability of skin fibroblasts in the dermis to create fiber and matrix components. Generally, a reduction in the amount of matrix leads to a decrease in skin thickness and deterioration of skin elasticity, causing the formation of wrinkles. That is, skin aging causes serious problems, such as elasticity loss, blood circulation disturbance and poor skin barrier function.
“UV light exposure generates free radicals, reactive oxygen species (ROS), radical species derived from active carbonyl compounds, etc. in and on the skin. These active species are considered major causes of damage to skin cells. Further, the active species induce DNA damage and attack cell membrane structures, leaving age spots. Moreover, the attack of the active species causes loss of the functions of collagen and fibers to make the skin moist, soft, smooth and elastic, resulting in accelerated wrinkling. The administration of antioxidants for the removal of free radicals may also be helpful in reducing skin wrinkles. However, not all antioxidants exhibit satisfactory effects against skin wrinkling. Direct observation is desirable to better evaluate the effects of antioxidants on the reduction of skin wrinkles. Many drugs and cosmetics are currently being investigated for their potential to reduce skin wrinkles caused by external environmental factors and internal mechanisms.”
As a supplement to the background information on this patent application, NewsRx correspondents also obtained the inventors’ summary information for this patent application: “The present invention is designed to solve the problems of the prior art, and therefore it is an object of the present invention to provide a composition effective in reducing skin wrinkles. It is another object of the present invention to provide a method effective in reducing skin wrinkles.
“In order to achieve the above objects, an aspect of the present invention provides a composition for reducing skin wrinkles, comprising a phosphodiesterase 5 (PDE5) inhibitor, or a pharmaceutically acceptable salt, solvate or hydrate thereof as an active ingredient.
“Another aspect of the present invention provides a new medical-use of a phosphodiesterase 5 (PDE5) inhibitor, or a pharmaceutically acceptable salt, solvate or hydrate thereof for reducing skin wrinkles.
“Still another aspect of the present invention provides a use of a phosphodiesterase 5 (PDE5) inhibitor, or a pharmaceutically acceptable salt, solvate or hydrate thereof in the manufacture of a composition (for example, medicament, functional food or cosmetics) for the improvement or reduction of skin wrinkles.
BRIEF DESCRIPTION OF DRAWINGS
“The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawings will be provided by the Office upon request and payment of the necessary fee.
“Other objects and aspects of the present invention will become apparent from the following description of embodiments with reference to the accompanying drawing in which:
“FIG. 1 graphically shows test results for the stimulatory efficacy of PDE5 inhibitors on the production of collagen having a great influence on the reduction of skin wrinkles;
“FIG. 2 shows photographs of a normal group (n=4) that was not irradiated with UV to induce wrinkles;
“FIG. 3 shows photographs of a negative control (n=6) that was irradiated with UV to induce wrinkles and treated with a medium (20% EtOH, 30% DW, 50% PEG) only without administration of any active ingredient;
“FIG. 4 shows photographs of a group (n=7) treated with 10 mM (about 5%) sildenafil after wrinkles were induced; and
“FIG. 5 shows photographs of a positive control (n=6) treated with 0.05% retinoic acid.”
For additional information on this patent application, see: LEE, Soo-Min; LEE, Sooheun; RYU, Keun-Ho; LEE, Bong-Yong; KIM, Jae-Sun; OH, Jung-Hoon; JEON, Ye-Ji. Composition for Reducing Skin Wrinkles Including Pde5 Inhibitor. Filed March 3, 2014 and posted July 3, 2014. Patent URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&u=%2Fnetahtml%2FPTO%2Fsearch-adv.html&r=2337&p=47&f=G&l=50&d=PG01&S1=20140626.PD.&OS=PD/20140626&RS=PD/20140626
Keywords for this news article include: Antioxidants, Chemistry, Protective Agents, Phosphodiesterases, Sk Chemicals Co. Ltd, Enzymes and Coenzymes.
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