Reports on Phytotherapy from Florida A&M University Provide New Insights (High Throughput Screening of Natural Products for Anti-mitotic Effects in MDA-MB-231 Human Breast Carcinoma Cells)
By a News Reporter-Staff News Editor at Drug Week — Researchers detail new data in Drugs and Therapies. According to news reporting originating from Tallahassee, Florida, by NewsRx correspondents, research stated, “Some of the most effective anti-mitotic microtubule-binding agents, such as paclitaxel (Taxus brevifolia) were originally discovered through robust National Cancer Institute botanical screenings. In this study, a high-through put microarray format was utilized to screen 897 aqueous extracts of commonly used natural products (0.00015-0.5mg/mL) relative to paclitaxel for anti-mitotic effects (independent of toxicity) on proliferation of MDA-MB-231 cells.”
Our news editors obtained a quote from the research from Florida A&M University, “The data obtained showed that less than 1.34 \% of the extracts tested showed inhibitory growth (IG50) properties <0.0183mg/mL. The most potent anti-mitotics (independent of toxicity) were Mandrake root (Podophyllum peltatum), Truja twigs (Thuja occidentalis), Colorado desert mistletoe (Phoradendron flavescens), Tou Gu Cao Speranskia herb (Speranskia tuberculata), Bentonite clay, Bunge root (Pulsatilla chinensis), Brucea fruit (Brucea javanica), Madder root (Rubia tinctorum), Gallnut of Chinese Sumac (Melaphis chinensis), Elecampane root (Inula Helenium), Yuan Zhi root (Polygala tenuifolia), Pagoda Tree fruit (Melia Toosendan), Stone root (Collinsonia Canadensis), and others such as American Witchhazel, Arjun, and Bladderwrack. The strongest tumoricidal herbs identified from amongst the subset evaluated for anti-mitotic properties were wild yam (Dioscorea villosa), beth root (Trillium Pendulum), and alkanet root (Lithospermum canescens). Additional data was obtained on a lesser-recognized herb: (S. tuberculata), which showed growth inhibition on BT-474 (human ductal breast carcinoma) and Ishikawa (human endometrial adenocarcinoma) cells with ability to block replicative DNA synthesis, leading to G2 arrest in MDA-MB-231 cells.”
According to the news editors, the research concluded: “These findings present relative potency of anti-mitotic natural plants that are effective against human breast carcinoma MDA-MB-231 cell division.”
For more information on this research see: High Throughput Screening of Natural Products for Anti-mitotic Effects in MDA-MB-231 Human Breast Carcinoma Cells. Phytotherapy Research, 2014;28(6):856-867. Phytotherapy Research can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell – www.wiley.com/; Phytotherapy Research – onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1573)
The news editors report that additional information may be obtained by contacting E. Mazzio, Florida A&M Univ, Coll Pharm & Pharmaceut Sci, Tallahassee, FL 32307, United States. Additional authors for this research include R. Badisa, N. Mack, S. Deiab and K.F.A. Soliman (see also Drugs and Therapies).
Keywords for this news article include: Florida, Tallahassee, United States, Drugs and Therapies, North and Central America
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