Recent Reports from Oregon State University Highlight Findings in Natural Products (Genetic insights into pyralomicin biosynthesis in Nonomuraea...

Life Science Weekly |

Recent Reports from Oregon State University Highlight Findings in Natural Products (Genetic insights into pyralomicin biosynthesis in Nonomuraea spiralis IMC A-0156) By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Life Science Research have been published. According to news reporting from Corvallis, Oregon, by NewsRx journalists, research stated, "The biosynthetic gene cluster for the pyralomicin antibiotics has been cloned and sequenced from Nonomuraea spiralis IMC A-0156. The 41 kb gene cluster contains 27 ORFs predicted to encode all of the functions for pyralomicin biosynthesis." The news correspondents obtained a quote from the research from Oregon State University, "This includes nonribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) required for the formation of the benzopyranopyrrole core unit, as well as a suite of tailoring enzymes (e.g., four halogenases, an O-methyltransferase, and an N-glycosyltransferase) necessary for further modifications of the core structure. The N-glycosyltransferase is predicted to transfer either glucose or a pseudosugar (cyclitol) to the aglycone. A gene cassette encoding C7-cyclitol biosynthetic enzymes was identified upstream of the benzopyranopyrrole-specific ORFs." According to the news reporters, the research concluded: "Targeted disruption of the gene encoding the N-glycosyltransferase, prlH, abolished pyralomicin production, and recombinant expression of PrlA confirms the activity of this enzyme as a sugar phosphate cyclase involved in the formation of the C7-cyclitol moiety." For more information on this research see: Genetic insights into pyralomicin biosynthesis in Nonomuraea spiralis IMC A-0156. Journal of Natural Products, 2013;76(5):939-46. (American Chemical Society - www.acs.org; Journal of Natural Products - www.pubs.acs.org/journal/jnprdf) Our news journalists report that additional information may be obtained by contacting P.M. Flatt, Dept. of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331-3507, United States. Additional authors for this research include X. Wu, S. Perry and T. Mahmud (see also Life Science Research). Keywords for this news article include: Oregon, Genetics, Corvallis, United States, Life Science Research, North and Central America. Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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