New Physics Research Data Have Been Reported by Researchers at University of Calcutta (Role of functionality in two-component signal transduction: a...

Life Science Weekly |

New Physics Research Data Have Been Reported by Researchers at University of Calcutta (Role of functionality in two-component signal transduction: a stochastic study) By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Physics Research have been published. According to news originating from Kolkata, India, by NewsRx correspondents, research stated, "We present a stochastic formalism for signal transduction processes in a bacterial two-component system. Using elementary mass action kinetics, the proposed model takes care of signal transduction in terms of a phosphotransfer mechanism between the cognate partners of a two-component system, viz., the sensor kinase and the response regulator." Our news journalists obtained a quote from the research from the University of Calcutta, "Based on the difference in functionality of the sensor kinase, the noisy phosphotransfer mechanism has been studied for monofunctional and bifunctional two-component systems using the formalism of the linear noise approximation. Steady-state analysis of both models quantifies different physically realizable quantities, e.g., the variance, the Fano factor (variance/mean), and mutual information. The resultant data reveal that both systems reliably transfer information of extracellular environment under low external stimulus and in a high-kinase-and-phosphatase regime." According to the news editors, the research concluded: "We extend our analysis further by studying the role of the two-component system in downstream gene regulation." For more information on this research see: Role of functionality in two-component signal transduction: a stochastic study. Physical Review E, Statistical, Nonlinear, and Soft Matter Physics, 2014;89(3):032713 (see also Physics Research). The news correspondents report that additional information may be obtained from A.K. Maity, Dept. of Chemistry, University of Calcutta, 92 A P C Road, Kolkata 700 009, India. Additional authors for this research include A. Bandyopadhyay, P. Chaudhury and S.K Banik. Keywords for this news article include: Asia, India, Kinase, Kolkata, Physics Research, Enzymes and Coenzymes. Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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