New Campylobacter jejuni Findings from Institute of Biomedical Sciences Discussed (Cystic Fibrosis Transmembrane Conductance Regulator Reduces...

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New Campylobacter jejuni Findings from Institute of Biomedical Sciences Discussed (Cystic Fibrosis Transmembrane Conductance Regulator Reduces Microtubule-Dependent Campylobacter jejuni Invasion)

By a News Reporter-Staff News Editor at Food Weekly News -- Current study results on Gram-Negative Bacteria - Campylobacter jejuni have been published. According to news reporting originating in Tokushima, Japan, by VerticalNews journalists, research stated, "Campylobacter jejuni is a foodborne pathogen that induces gastroenteritis. Invasion and adhesion are essential in the process of C. jejuni infection leading to gastroenteritis."

The news reporters obtained a quote from the research from the Institute of Biomedical Sciences, "The mucosal layer plays a key role in the system of defense against efficient invasion and adhesion by bacteria, which is modulated by several ion channels and transporters mediated by water flux in the intestine. The cystic fibrosis transmembrane conductance regulator (CFTR) plays the main role in water flux in the intestine, and it is closely associated with bacterial clearance. We previously reported that C. jejuni infection suppresses CFTR channel activity in intestinal epithelial cells; however, the mechanism and importance of this suppression are unclear. This study sought to elucidate the role of CFTR in C. jejuni infection. Using HEK293 cells that stably express wild-type and mutated CFTR, we found that CFTR attenuated C. jejuni invasion and that it was not involved in bacterial adhesion or intracellular survival but was associated with microtubule-dependent intracellular transport. Moreover, we revealed that CFTR attenuated the function of the microtubule motor protein, which caused inhibition of C. jejuni invasion, but did not affect microtubule stability. Meanwhile, the CFTR mutant G551D-CFTR, which had defects in channel activity, suppressed C. jejuni invasion, whereas the Delta F508-CFTR mutant, which had defects in maturation, did not suppress C. jejuni invasion, suggesting that CFTR suppression of C. jejuni invasion is related to CFTR maturation but not channel activity. When these findings are taken together, it may be seen that mature CFTR inhibits C. jejuni invasion by regulating microtubule-mediated pathways."

According to the news reporters, the research concluded: "We suggest that CFTR plays a critical role in cellular defenses against C. jejuni invasion and that suppression of CFTR may be an initial step in promoting cell invasion during C. jejuni infection."

For more information on this research see: Cystic Fibrosis Transmembrane Conductance Regulator Reduces Microtubule-Dependent Campylobacter jejuni Invasion. Infection and Immunity, 2017;85(10):201-212. Infection and Immunity can be contacted at: Amer Soc Microbiology, 1752 N St NW, Washington, DC 20036-2904, USA. (American Society for Microbiology -; Infection and Immunity -

Our news correspondents report that additional information may be obtained by contacting T. Shimohata, Tokushima Univ, Inst Biomed Sci, Dept. of Prevent Environm & Nutr, Tokushima, Japan. Additional authors for this research include J. Kido, S. Amano, S. Hatayama, A.Q. Nguyen, Y. Sato, Y. Kanda, A. Tentaku, S. Fukushima, M. Nakahashi, T. Uebanso, K. Mawatari and A. Takahashi.

Keywords for this news article include: Tokushima, Japan, Asia, Cystic Fibrosis Transmembrane Conductance Regulator, Respiratory Tract Diseases and Conditions, Digestive System Diseases and Conditions, Pancreatic Diseases and Conditions, Foodborne Diseases and Conditions, Lung Diseases and Conditions, Membrane Transport Proteins, Membrane Glycoproteins, Cytoplasmic Structures, Gram-Negative Bacteria, Epsilonproteobacteria, Campylobacter jejuni, Cellular Structures, Intracellular Space, Membrane Proteins, Chloride Channels, Carrier Proteins, Proteobacteria, Microtubules, Cytoskeleton, Institute of Biomedical Sciences.

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