Navidea Biopharma (NAVB) are Expanding the Reach of Lymphoseek

Stephen L Kanaval  |

Unless you really nailed your biology homework, you might not know what a macrophage is and what it does. A macrophage is kind of like a trash collector in the body, removing diseases, dead cells, and other foreign particles. Macrophages can be extremely helpful in diagnosing immune dysfunction because when there is a malfunction the macrophages tend to behave improperly. In a body that might be at risk, macrophages become over active. Navidea Biopharmaceuticals (NAVB), using a receptor in the macrophages, has created an FDA-approved immunodiagnostic called Lymphoseek®. The product itself is a radioactive agent that can be used for lymphatic mapping and guiding sentinel lymph node biopsy (a procedure most common in breast cancer that determines if a primary tumor has entered a lymphatic system).

Lymphoseek has some very positive data to support it:

  • 97% of patients had lymph nodes identified by the product.
  • Lymphoseek provides advanced data to help patients make decisions after evaluations.
  • No patients have experienced adverse reactions from Lymphoseek.

Navidea is working to expand Lymphoseek’s diagnostic reach to arthritis and cervical cancer, and also to commercialize the Lymphoseek’s FDA approval. Lymphoseek is built off the Manocept™ platform, which is able to target the CD206 mannose receptor, as mentioned above. The Manocept platform allows for targeted diagnostic analysis or treatment. This type of versatility allows Navidea to develop drugs and disease-fighting therapies that can all be delivered through the same patented system.

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