It's what every biotech investor dreams of: transformational advances in healthcare technologies that allow us to live for centuries and accumulate wealth exponentially. Patrick Cox, editor of the Transformational Technology Alert, is doing his part to make the dream reality. In this interview, Cox tells The Life Sciences Report about two companies with proprietary intellectual property in DNA-based therapeutics and regenerative medicine that could change the world.
The Life Sciences Report: Patrick, you will be speaking at the Altegris Advisors LLC/Mauldin Economics conference in San Diego later in May on the topic of investing in a transformational world. What do you mean by "transformational?"
Patrick Cox: Transformational technologies change existing paradigms by causing massive disruption—destroying old industries while creating new ones. That is what we are now experiencing: The old ways are obsolescing as new solutions emerge.
TLSR: How is this playing out in the life sciences realm?
PC: Innovations and discoveries in the life sciences are bigger than in other fields. Especially with DNA, which is an ancient system of incredible complexity and sophistication. DNA-based breakthroughs in medical research are personally valuable to most people. The new DNA-based industry aims at curing diseases and extending the healthy portion of our lives significantly.
TLSR: What transformational companies do you like in the biotech world?
PC: I am not going to give away the companies I will be talking about at the San Diego conference.
TLSR: Even irrational beliefs can have market consequences.
PC: Correct, but how do you predict what irrationality will do? In the long run, productivity and profits will triumph.
TLSR: Are DNA-based vaccines predicted to be cheaper than the status quo?
PC: The status quo does not approach the same clinical targets. However, DNA vaccines are not terribly expensive. The plasmids on a large scale are inexpensive, and electroporation is not a costly technology. There is one machine and a disposable unit, so the production cost is not significant. These are pharmaceutical products, so the production cost does not really matter, as the prices are market-based.
TLSR: When a company makes a transformational breakthrough, such as in DNA vaccines, does this strengthen our economy?
PC: The macroeconomic drivers in life sciences are tied to the radical increase in life span that has taken place very recently. Since the American Revolution, life spans have more than doubled. In my lifetime, the average life span has increased by more than 30 years. We still have a social service model instituted when birth rates were high and life spans were relatively short. In 1950, just before I was born, I think there were about 16 workers for every retired person. Today, it's fewer than three working persons per retired person. Moreover, healthcare costs go up as we get older. Alzheimer's disease and heart disease are incredibly expensive to treat and live with. When people lived to 65 on average, those diseases were not particularly evident.
TLSR: What about regenerative medicine?
PC: Regenerative medicine is the most transformational of all the medical therapies, because it has the potential to reverse cellular aging. BioTime is working with stem cells that it can program to become cardiomyocytes, heart muscle cells. BioTime's researchers have seen the cells self-assemble in a dish and begin to beat like a heart! And we know from animal experiments that rejuvenated cardiomyocytes can integrate into the heart and heal damaged heart muscles. Stem cells are looking good.
TLSR: Does BioTime have a product based on this stem cell research?
PC: It has a subsidiary, ReCyte Therapeutics Inc., which is developing a delivery system for rejuvenated cardiomyocytes—sort of an epoxy that can be molded. It can make joints or flesh in reconstructive surgery. It creates a permanent matrix in which stem cells prosper, including in the heart. Third-party testing has validated this approach. But ReCyte Therapeutics' first product is slated to be endothelial precursors.
TSLR: What are endothelial precursors?
PC: Among gerontologists, there is a saying, "You're as old as your endothelium." The endothelium is a thin layer of cells inside the entire circulatory system—heart, arteries, capillaries. When you are young, it provides nitric oxide, which is an important neurotransmitter because it passes through cell walls. It is very short-lived, but it is responsible for vessel dilation. If you need additional blood flow for exercise or injury repair, or for any reason, the endothelium activates nitric oxide, which causes dilation and increases blood flow. When that does not work, there are all kinds of consequences—erectile dysfunction, hypertension, macular degeneration. It is a big killer, which is why the endothelium is the most important target for regenerative medicine.
TLSR: How can this process be industrialized?
PC: The endothelium does not regenerate by cell replication inside the cell walls. It exists as precursor cells inside the marrow of the larger bones, where the immune system resides. These cells simply circulate, find where they are needed, and engraft. If you were injected with your own endothelial precursor cells, they would migrate to the marrow of your large bones. We now know, from doing research on blood cancers, that the immune system can be rebooted without ablating bone marrow to generate replacement of old, sick endothelial precursors with new ones.
Michael West, who founded Geron Corp. (GERN) and now owns Geron's IP, did this with cows. And Geron and BioTime have merged on the stem cell/regenerative medicine front. Dr. West ablated the bone marrow of one group of cows and then injected epithelial precursors. But as a control, he also injected the precursors into cows without ablative bone marrow. In both groups, the younger, healthier endothelial precursors replaced the older, unhealthier ones.
Blood cancer researchers have found the same thing. This is really a remarkably simple process. It is now possible to take cells from the patient, convert them to induced pluripotent stem cells [able to become any kind of cell], engineer them to become endothelial precursors, and then simply inject them into the patient. The precursors migrate to the bone marrow and replace the older, nonfunctioning or less functional endothelium with what is essentially a child's endothelium in terms of health and functionality.
TLSR: That sounds transformational in more ways than one.
PC: I'll say.
TLSR: How will the costs of healthcare decrease in your transformational model?
PC: Think about the cost of a heart attack and the subsequent care—hundreds of thousands of dollars over a lifetime right now. I predict that the cost of endothelial precursor therapy will eventually get that cost down to $10,000. Given the hundreds of thousands of dollars we spend on an Alzheimer's patient today, it's very unlikely that any of the drugs or the cells that are used to cure Alzheimer's will cost even a significant fraction of today's price tag.
TLSR: There will be less need for palliative care and radical surgery?
PC: That is right. Also, working careers will lengthen appreciably. People in the investment business know the impact of exponential growth on a portfolio. Despite the fact that everybody is worked up about income inequality, the real cause of income inequality is the fact that we have a much older and larger population. Older folks have worked long and grown their portfolios. As we extend life spans and careers, income inequality will increase spectacularly, as older people continue to get richer.
TLSR: What kind of life span do you look at for the average human of the future?
PC: A life span of centuries. Right now, our lives are bounded by our Hayflick limit—we are born with potential for about 120 cell replications. This is determined by the telomere, which is the nub on the zipper of an individual's DNA. Every time a cell replicates, we use up one of the telomere nubs. When we run out, the cell simply stops reproducing. Modern medicine is mostly trying to stop diseases that kill us before we reach our Hayflick limit. And we will do that. We will cure heart disease, cancer, Alzheimer's, liver disease; we will beat viruses; and we will end the factors that cause accelerated aging—inflammation, fibrosis, mitochondrial dysfunction. This will take us to a life span of about 120 years.
Beyond that, we will turn to regenerative medicine to rejuvenate cells, and there are a number of ways to do this. The first major breakthrough will probably be endothelial precursors rejuvenating endothelium, which will largely eliminate heart disease and stroke.
TLSR: Are we going to end up with 20 billion people who are 300 years old?
PC: That is a myth. If you look at the math, we are in serious depopulation right now. The West is disappearing. Iceland's birth rate is so low that the country has come to grips with the fact that it is disappearing as a culture. Japan is trying to increase its birth rates. Africa and the Middle East still have relatively high birth rates, but they are falling too. As they fall, we will see a diminishing global population. We are using a fraction of the earth's surface to produce food, minerals and energy. I am not at all worried about population.
TLSR: If you were able to live another 200 years, what would you do?
PC: I am interested in particle physics, and music and skateboarding.
TLSR: Thanks for your time today, Patrick.
PC: A pleasure.
Patrick Cox is the editor of Transformational Technology Alert. He has lived in the world of technology breakthroughs for the past 30 years. He has written more than 200 editorials for USA Today and has appeared in The Wall Street Journal and on CNN's "Crossfire" television program. In the late 1980s, he edited and published one of the first industry-insider software magazines, writing about topics like open-source and user-supported software long before those ideas were widely understood. Later, Cox wrote presentations and speeches for the CEO of Netscape. His consulting work has taken him to Fortune 500 boardrooms and inside the war rooms of national political candidates. His independent research is based solely on his investigations in transformational wealth-building companies and close consultation with Nobel Prize-winning economists and scientists.
Source: Peter Byrne of The Life Sciences Report (5/8/14)
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