IPO Report: Vascular Biogenics (VBLX)

Francis Gaskins |

Vascular Biogenics (VBLX) is a clinical-stage biopharmaceutical company committed to the discovery, development and commercialization of first-in-class treatments for cancer and immune-inflammatory diseases. It is headquartered in Or Yehuda, Israel,

Nineteen other companies are scheduled to IPO for the week of July 28, 2014.  The full IPO calendar is available at IPOpremium.

The manager and co-managers are Deutsche Bank Securities, Wells Fargo Securities

Joint Managers: JMP Securities, Needham, Oppenheimer

VBLX scheduled a $76 million IPO with a market capitalization of $259 million at a price range midpoint of $14 for Thursday, July 31, 2014 on the Nasdaq.  SEC filings

VLBX IPO Overview

VBLX is a clinical-stage biopharmaceutical company committed to the discovery, development and commercialization of first-in-class treatments for cancer and immune-inflammatory diseases.

VLBX Valuation



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Vascular Biogenics (VBLX)








Conclusion on VBLX's IPO

The rating is neutral.

Existing shareholders have indicated an interest in buying $35 million on the IPO.

3.2 times book value

VBLX's Business

VBLX is a clinical-stage biopharmaceutical company committed to the discovery, development and commercialization of first-in-class treatments for cancer and immune-inflammatory diseases.

VBLX’s clinical pipeline is based on two distinct, proprietary platform technologies that leverage the body’s natural physiologic and genetic regulatory elements.

To date, VBLX has developed two programs based on these platforms—an oncology program and an anti-inflammatory program.

VBLX’s lead product candidate from its oncology program, VB-111, is a gene-based biologic that VBLX is initially developing for recurrent glioblastoma, or rGBM, an aggressive form of brain cancer.

VBLX fast track designation

VBLX has obtained fast track designation for VB-111 in the United States for prolongation of survival in patients with glioblastoma that has recurred following treatment with standard chemotherapy and radiation.

VBLX orphan drug designation

VBLX has also received orphan drug designation in both the United States and Europe.

VBLX planned Phase 3 trial

The FDA has concurred with the design and planned analyses of VBLX’s Phase 3 pivotal trial of VB-111 in rGBM pursuant to a special protocol assessment, or SPA. VBLX intends to begin this trial by the end of the first quarter of 2015, subject to the FDA being satisfied with the potency release assay to be used in the trial.

VB-201 phase 2 clinical trial

VBLX’s lead product candidate from its anti-inflammatory program, VB-201, is an oral small molecule VBLX is currently evaluating in Phase 2 clinical trials for psoriasis and for ulcerative colitis. VBLX has completed enrollment of both of these Phase 2 clinical trials and VBLX expects top-line results from these trials in the first quarter of 2015.

VBLX’s oncology program is based on its proprietary Vascular Targeting System, or VTS, platform technology, which utilizes genetically targeted therapy to destroy newly formed, or angiogenic, blood vessels.

VBLX believes this technology will allow VBLX to develop product candidates for multiple oncology indications.

VBLX’s anti-inflammatory program is based on the use of its Lecinoxoid platform technology. Lecinoxoids are a novel class of small molecules VBLX developed that are structurally and functionally similar to naturally occurring molecules known to modulate inflammation.

VBLX believes its two distinct platform technologies provide it with an opportunity to develop a diversified portfolio of product candidates targeting both orphan indications and large markets.

VBLX Dividend Policy

No dividends are planned

VBLX's Intellectual Property

As of March 14, 2014, VBLX had 108 granted patents and 81 applications pending worldwide for its oncology program and VTS platform technology and 86 granted patents and 86 patent applications pending worldwide for its anti-inflammatory program and Lecinoxoid family of compounds.

VBLX's Competition

In particular, VB-111 may face competition from currently approved drugs and drug candidates under development by others to treat rGBM. In May 2009, the FDA granted accelerated approval to Avastin (bevacizumab), which is an angiogenesis inhibitor, to treat patients with rGBM at progression after standard first-line therapy.

In addition to bevacizumab, a number of companies are conducting late-stage clinical trials to test targeted drugs focused on angiogenesis inhibition for the treatment of ovarian cancer, including, among others, Amgen’s trebananib, Boehringer Ingelheim’s nintedanib and GlaxoSmithKline’s Votrient.

5% Stockholders

The Keffi Group VI LLC         24.0% 

Aurum Ventures M.K.I. Ltd         23.5%  

Persons affiliated with Pitango Ventures        11.7%   

Persons affiliated with J.J.D. Holdings        7.9%

Prof. Dror Harats         10.9%   

Mr. Jecheskiel Gonczarowski        14.6%   

Use of Proceeds

VBLX intends to use the $68 million in proceeds from its IPO as follows:

$30.0 million to fund clinical development costs of VB-111;

$4.5 million to fund development costs of VB-201;

$6.5 million for pre-clinical and early clinical development of follow-on Lecinoxoid product candidates;

$8.0 million for costs associated with the construction of its VB-111 manufacturing facility;

$0.7 million, representing 1% of the net proceeds of this offering, to satisfy a payment obligation triggered upon its initial public offering pursuant to an agreement with Tel Hashomer—Medical Research, Infrastructure and Services Ltd.; and

the remainder for working capital and general corporate purposes, including funding the costs of operating as a public company.

DISCLOSURE: The views and opinions expressed in this article are those of the authors, and do not represent the views of equities.com. Readers should not consider statements made by the author as formal recommendations and should consult their financial advisor before making any investment decisions. To read our full disclosure, please go to: http://www.equities.com/disclaimer


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