DelMar Pharmaceuticals’ VAL-083 Continues to Show Promise in Treating Resistant Cancers

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Continuing their groundbreaking research to find cancer treatment solutions to those resistant to alkylation-based chemotherapy, DelMar Pharmaceuticals, Inc. ($DMPI) presented "The unique mechanism of action of dianhydrogalactitol (VAL-083) may provide a new treatment option for chemo-resistant cancers," at the American Association for Cancer Research (AACR) New Horizons in Cancer Research Conference: Bringing Cancer Discoveries to Patients in Shanghai, China. The data highlights the Company's recent research supporting VAL-083 as a chemotherapeutic agent in the treatment of a variety of cancers. 

"Poor outcomes due to drug-resistance remains a significant unmet clinical challenge for many cancer patients. New agents are needed to address treatment-resistant cancers," stated Jeffrey Bacha, President and CEO of DelMar Pharmaceuticals. "Historical clinical data from the US National Cancer Institute (NCI), along with our own preclinical and clinical trial data, all support the activity of VAL-083 against a range of tumor types via a novel mechanism of action that we believe could provide improved treatment options for patients."

The presentation was summarized as follows:

●      VAL-083 activity is independent of O6-methylguanine-DNA methyltransferase (MGMT) expression and overcomes temozolomide (TMZ)-resistance in GBM cell lines;

●      VAL-083 overcomes cisplatin-resistance in ovarian cancer and NSCLC cell lines;

●      VAL-083 overcomes tyrosine kinase inhibitor (TKI)-resistance in non-small cell lung cancer (NSCLC) cell lines, including H1975 with T790M mutation in EGFR;

●      VAL-083 displays synergy and super-additivity with both cisplatin and oxaliplatin in NSCLC cell lines, including TKI-resistant cells in vitro and in vivo;

●      VAL-083 activity is independent of p53 status than in comparison to platinum-based chemotherapy; and

●      VAL-083 is active against pediatric brain tumors in vitro including high grade gliomas (HGG), GBM cancer stem cells and p53 mutated SHH medulloblastoma.

"The data presented today support expanded clinical use of VAL-083 under its current lung-cancer approval in China,” said Bacha, “and also serve as the basis for global development of VAL-083 in important cancer indications such as GBM, NSCLC and ovarian cancer."

A biopharmaceutical company focused on the development and commercialization of new cancer therapies, Del Mar has announced a number of promising breakthroughs with VAL-083 in 2015. Earlier this month, the company presented positive data in the treatment of non-small cell lung cancer at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. A first-in-class, small-molecule chemotherapeutic, VAL-083 has proven to be safe and effective in treating various cancers in over 40 Phase I and II clinical studies. Currently, the anti-cancer drug is approved to treat chronic myelogenous leukemia lung cancer in China, and is currently undergoing clinical trials in the US.

Del Mar is leading the way to a cancer-free world. Their breakthrough drug and consistent positive results throughout various clinical trials is helping fill the devastating gaps in modern cancer treatments. "These data represent important steps toward realizing our vision,” said Bacha, “of leveraging historical clinical data with new research into the mechanism of VAL-083 to address modern unmet medical needs in the treatment of cancer."

Equities.com had the opportunity to interview Jeffrey Bacha, President and CEO of DelMar Pharmaceuticals. The interview can be watched here. For more information about DelMar Pharmaceuticals, visit www.delmarpharma.com.

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