Amarantus Seeks to Combat Parkinson’s-related Dyskinesia with Orphan Drug Designation

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Parkinson's disease is a neurodegenerative brain disorder that causes tremors, rigidity, slowed movements and trouble with balance. While levodopa-based therapies are the most commonly-prescribed treatments for Parkinson’s, their effectiveness decreases over time, resulting in various side effects, particularly Levodopa-induced dyskinesia. The once beneficial doses of the drug designed to replace dopamine loss can leave patients unable to perform daily routine tasks. Amarantus Bioscience Holdings, Inc. (AMBS) ,a biotechnology company developing treatments and diagnostics for diseases in the areas of neurology and orphan diseases, is one step closer to providing a solution for those suffering from Levodopa-induced dyskinesia.

Amarantus Bioscience has submitted a request to the US FDA for orphan drug designation (ODD) for eltoprazine in the treatment of levodopa-induced dyskinesia (PD-LID). The FDA Orphan Drug Designation program provides a special status to drugs and biologics intended to treat, diagnose or prevent orphan diseases and disorders that affect fewer than 200,000 people in the US.

“A successful application to the US FDA for ODD for eltoprazine in PD LID would complete the transition of our therapeutics portfolio into the orphan drug arena, thereby squarely positioning Amarantus as an orphan drug company,” said Gerald E. Commissiong, President and CEO of Amarantus.

Working to Improve Quality of Life

Eltoprazine is a small molecule 5HT1A/1B partial agonist in clinical development for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID), adult attention deficit hyperactivity disorder (ADHD) and Alzheimer’s aggression.To date, Eltoprazine has been evaluated in over 680 human subjects, and has a well-established safety profile.

There are an estimated one million people living with Parkinson's disease in the United States. While there is no cure for Parkinson’s, various medications and therapies are utilized to treat the symptoms. Amarantus’ latest development furthers their reputation as a premiere representative of the biotechnology community that strives to develop treatments that improve the quality of life for Parkinson’s patients. 

For more information about Amarantus Bioscience, visit www.amarantus.com.

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