Reports Outline Magnetic Resonance Research Research from University of BonnMagnetic Resonance ResearchNewsRx.com
By a News Reporter-Staff News Editor at Science Letter -- Investigators discuss new findings in Magnetic Resonance Research. According to news reporting from Bonn, Germany, by NewsRx journalists, research stated, "One focus of current nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) investigation is the hyperpolarization of biologically relevant substrates. In this study, the application of parahydrogen-induced polarization (PHIP) to amino carboxylic acids was enabled by protonation of the amino group as well as of the carboxylic acid."
The news correspondents obtained a quote from the research from the University of Bonn, "Due to the donor character of these functional groups, they usually act as ligands at the active catalytic sites. To enable parahydrogenation, blocking of the catalytic sites by the functional groups has to be avoided. In a new approach, this was realized via protonation of the starting material. For the first time PHIP spectra of allylglycine, vigabatrin and gamma-amino-butyric acid (GABA) were generated. The feasibility of the hydrogenation of amino carboxylic acids without using a protection group supersedes the deprotection reaction usually required."
According to the news reporters, the research concluded: "Hence, hydrogenation after protonation of the substrate opens the class of free dehydroamino carboxylic acids to PHIP."
For more information on this research see: Application of Parahydrogen-Induced Polarization to Unprotected Dehydroamino Carboxylic Acids. Applied Magnetic Resonance, 2013;44(1-2):267-278. Applied Magnetic Resonance can be contacted at: Springer Wien, Sachsenplatz 4-6, PO Box 89, A-1201 Wien, Austria. (Springer - www.springer.com; Applied Magnetic Resonance - www.springerlink.com/content/0937-9347/)
Our news journalists report that additional information may be obtained by contacting T. Trantzschel, University of Bonn, Inst Phys & Theoret Chem, Bonn, Germany (see also Magnetic Resonance Research).
Keywords for this news article include: Bonn, Europe, Germany, Carboxylic Acids, Organic Chemicals, Magnetic Resonance Research
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