Scientists at Technion-Israel Institute of Technology Release New Data on NanotechnologyNanotechnologyNewsRx.com
By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Nanotechnology are discussed in a new report. According to news reporting originating from Haifa, Israel, by NewsRx correspondents, research stated, "Releasing drug molecules at their targets with high spatial and temporal accuracy could aid numerous clinical applications which require low systemic damage and low side effects. Nano-carriers of drugs are an attractive solution for such task, allowing specific accumulation in tumors and gradual release of their payload."
Our news editors obtained a quote from the research from the Technion-Israel Institute of Technology, "Here, we utilize gold nanospheres conjugated to Rituximab, an anti-CD20 monoclonal antibody-based drug, for carrying and releasing the drug upon irradiation of specifically tailored femtosecond laser pulses. The released anti-CD20 molecules retain their functionality and ability of triggering the complement-dependent cytotoxicity. This effect comes in addition to cell necrosis caused by the plasmonic nanometric shock waves emanating from the nanospheres and rupturing the plasma membranes."
According to the news editors, the research concluded: "Main advantages of the presented technique include high spatial and temporal resolution, low toxicity and high repeatability and consistency due to the morphological stability of the nanospheres."
For more information on this research see: Controlled release of Rituximab from gold nanoparticles for phototherapy of malignant cells. Journal of Controlled Release, 2012;162(2):303-9. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
The news editors report that additional information may be obtained by contacting G. Bisker, Dept. of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel (see also Nanotechnology).
Keywords for this news article include: Asia, Biotechnology, Haifa, Israel, Nanoparticle, Nanotechnology, Medical Devices, Controlled Release, Emerging Technologies, Monoclonal Antibodies.
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