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IPO Report: BIND Therapeutics (BIND)

By  +Follow September 19, 2013 2:04PM
Tickers Mentioned:

BIND Therapeutics ($BIND) is a nanomedicine platform company with major collalaboration partners, and is initially focused on oncology (cancer).  Collaboration partners announced to date in 2013: Amgen (AMGN) market cap of $79 billion; Pfizer (PFE) , market cap of $291 billion; and AstraZeneca (AZN) , market cap of $62 billion.

BIND id one of nine IPOs are scheduled for this week, 12 for next week. The full IPO calendar can be found at IPOpremium

BIND is based in Cambridge, MA, and scheduled a $100 million IPO with a market capitalization of $413 million at a price range mid-point of $15 milliion, Friday, September 20, 2013.

The S-1 was filed September 9, 2013.   Manager, Joint Managers: Credit Suisse; Cowen.  Co-Managers: Stifel; JMP Securities


Collaboration objectives: to develop Accurins based on therapeutic payloads from their product pipelines, with the potential to achieve a total of over $1 billion in upfront and future milestone payments, including over $450 million in pre-commercial milestones.


Accumulated deficit: $82.5 million, which is relatively low for a biopharma with stage 2 trials and a very good slate of collaboration partners. The price-to-book ratio is 3.3, which is very competitive.

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BIND Therapeutics (BIND)










Buy BIND on the IPO.


BIND is a clinical-stage nanomedicine platform company developing Accurins, novel targeted and programmable therapeutics.

Accurins are designed with specified physical and chemical characteristics to target specific cells or tissues and concentrate a therapeutic payload at the site of disease to enhance efficacy while minimizing adverse effects on healthy tissues.

BIND's strategy is to leverage its medicinal nanoengineering platform to develop its own pipeline of Accurins, initially in oncology, as well as Accurins in collaboration with biopharmaceutical companies.

The lead drug candidate, BIND-014, is in Phase 2 clinical trials for non-small cell lung cancer, or NSCLC, and metastatic castrate-resistant prostate cancer, or mCRPC.


BIND believes Accurins represent the next stage in the evolution of cancer therapy. Accurins are nanoparticles containing a therapeutic payload and are designed to target tumors at three levels: tissue, cellular and molecular. They combine this triple targeting with a prolonged circulation time to concentrate the therapeutic payload at the targeted disease site, where it is then released in a controlled and timely manner.

Accurins have the potential to significantly increase the net clinical benefit of the therapeutic payload and result in efficacy and safety not currently achievable through other therapeutic approaches.

Accurin graphic

Lead product candidate

BIND's lead Accurin drug candidate, BIND-014, is a prostate-specific membrane antigen, or PSMA, targeted Accurin that contains docetaxel. PSMA is a clinically-validated tumor marker expressed on prostate cancer cells and the blood vessels of many types of non-prostate solid tumors, including NSCLC. Docetaxel, marketed as Taxotere, is one of the most commonly used cancer chemotherapy drugs. It is approved by the U.S. Food and Drug Administration, or FDA, for the treatment of breast cancer, NSCLC, mCRPC, head and neck cancer, and gastric cancer.

Taxotere achieved global sales of approximately $3 billion in 2009, the year prior to its loss of marketing exclusivity in the United States, and generic docetaxel continues to be a mainstay in cancer treatment despite its significant side effects. These side effects include neutropenia, anemia, infection, fluid retention and edema, neuropathy, rash, mucositis, fatigue, muscle weakness, nail loss, hair loss and even death.

Clinical trials

In preclinical studies, BIND-014 demonstrated that its ability to destroy tumor cells is differentiated from, and superior to, Taxotere

BIND is in Phase 2 clinical trials to evaluate the level of clinical activity of BIND-014 in NSCLC and mCRPC and expect to report data from these studies in the second half of 2014.

To date, BIND has clinically tested BIND-014 in over 45 patients with advanced or metastatic cancer who failed prior therapies.

In the Phase 1 clinical trial, of the 28 patients who received BIND-014 once every three weeks, to date there has been one complete response in a patient with cervical cancer and three partial responses in patients with NSCLC, mCRPC and ampullary cancer.

A complete response generally refers to the disappearance of all signs of cancer in response to treatment, while a partial response generally refers to a decrease in the size of the tumor or in the extent of cancer in the body.

Five additional patients had stable disease lasting longer than 12 weeks.

Management team

BIND's management team has extensive experience in the development, regulatory approval and commercialization of nanotechnology drugs. Currently, the two leading nanotechnology cancer drugs are Doxil, a liposomal doxorubicin, and Abraxane, an albumin nanoparticle paclitaxel.

BIND's chief executive officer was the president and chief operating officer of SEQUUS Pharmaceuticals, Inc., the company that developed and commercialized Doxil. Both BIND's chief medical officer and BIND's head of regulatory affairs served in those roles at Abraxis Bioscience, Inc., the company that developed Abraxane.

Platform development

BIND's platform originated from the pioneering nanotechnology research at the Massachusetts Institute of Technology and Brigham and Women's Hospital/Harvard Medical School of BIND's scientific founders and directors Dr. Robert Langer and Dr. Omid Farokhzad. BIND's scientists and engineers continue to advance this technology to produce the next generation of targeted nanomedicines.

Intellectual property

BIND protects its medicinal engineering platform through 16 issued U.S. patents and 50 U.S. patent applications, in some cases with foreign counterparts relating to elements of Accurin candidates.


Current second-line treatments for non-small cell lung cancer (NSCLC) include docetaxel and other chemotherapy agents such as gemcitabine and vinorelbine, as well as molecularly-targeted therapies such as erlotinib and gefitinib, which are used to treat patients with mutations in epidermal growth factor receptor, or EGFR, and crizotinib, which is used in the small subset of patients that have a mutation in anaplastic lymphoma kinase, or ALK.

In addition, two monoclonal antibodies, Bristol-Myers Squibb's nivolumab that targets PD-1, and F. Hoffmann-La Roche Ltd's MPDL3280A that targets PD-L1, are currently in Phase 2 clinical trials for NSCLC. Both are immunomodulators that block the activation of programmed cell death receptor. In mCRPC, in addition to first-line chemotherapy agents such as docetaxel, the treatment paradigm is evolving to include use of hormonal therapies such as abiraterone and enzalutamide prior to the administration of chemotherapies, which therapies are currently mainly used in the post-chemotherapy setting.

Other similar drugs are also being developed. Cabazitaxel (marketed as Jevtana), a second-line taxane chemotherapeutic, is also being tested in clinical studies against docetaxel for efficacy in metastatic castrate-resistant prostate cancer (mCRPC).

In addition, other companies are developing therapies targeting prostate-specific membrane antigen (PSMA) to treat mCRPC, including an antibody-drug conjugate, or ADC, by Progenics Pharmaceuticals, Inc. and a Bispecific T Cell Engager, or BITE, antibody by Bayer Healthcare in collaboration with Amgen.

BIND also faces competition from numerous companies utilizing other nanomedicine platforms to develop targeted therapies, including platforms focused on albumin nanoparticles, liposomes and polymeric nanoparticles.

5% stockholders pre-IO

Entities affiliated with Polaris Venture Partners V, L.P., 18%
Flagship Ventures Fund 2004, L.P., 13.9%
RUSNANO, 11.5%
DHK Investments, LLC, 8.6%
ARCH Venture Fund VII, L.P., 8.5%
NanoDimension, L.P. , 6%

Financing history

Since inception and through March 31, 2013, BIND raised an aggregate of $94.7 million to fund operations, of which $6.5 million was through collaborations and license agreements, $76.2 million was from the sale of preferred stock and convertible debt securities, $4.8 million was from government grants and $7.2 million was from borrowings under an original credit facility as well as capital leases.

As of March 31, 2013, cash and cash equivalents were $11.9 million, of which $3.4 million was held by BIND's Russian subsidiary designated solely for use in its operations. As of March 31, 2013, BIND also had $1.4 million in restricted cash held in the Russian subsidiary.

In addition, in June 2013 BIND issued and sold additional shares of Series D preferred stock to existing investors for $8.7 million in gross proceeds and borrowed $4.5 million under an amended and restated credit facility with Hercules Technology III, L.P., or Hercules, of which $2.3 million was used to repay the outstanding principal balance under the original facility.

Use of proceeds

BIND expects to net $63 million from its IPO. Proceeds are allocated to fund development of BIND-014, and for working capital and general corporate purposes.

BIND believes that the net proceeds from the IPO, together with cash and cash equivalents as of March 31, 2013, borrowings available under the credit facility and research and development funding that BIND expects to receive under existing collaborations, excluding any potential milestone payments, will fund operating expenses and capital expenditure requirements through at least mid-2015.

BIND expects the funding will enable the company to complete its ongoing Phase 2 clinical trials of BIND-014 in NSCLC and mCRPC and, if such trials are successful, to initiate pivotal Phase 3 trials in these indications.

Results for BIND
20 Apr 14 00:23:33
$BIND Trader's Buzzers - XOMA Corp (XOMA), Cerus Corporation (CERS), Chelsea ... http://t.co/KVIumUKVeo
Luther Cox
19 Apr 14 20:49:10
$BIND BIND Therapeutics Prese http://t.co/2cI2KCPEVu
19 Apr 14 16:26:38
BIND 9.58 Stock Charts $BIND BIND Therapeutics Inc. (NASDAQ) BIND Stock Chart - 1 Month http://bigcharts.marke http://t.co/SiqIM8FTES
Andie Andrewson
19 Apr 14 13:01:04
$BIND Trader's Buzzers - XOMA Corp (XOMA), Cerus Corporation (CERS), Chelsea ... http://t.co/CXY8c3g0F2
Major Brown
18 Apr 14 07:06:38
$BIND BIND THERAPEUTICS, INC Files SEC form 8-K, Other Events http://t.co/oCqa6158dC
Angelena Mosesuo
18 Apr 14 04:44:09
$BIND BIND Therapeutics Prese http://t.co/NzuTsIZP8X
Mind Equity
18 Apr 14 04:06:48
$BIND BIND Therapeutics Prese http://t.co/eV7mKbuBNP
16 Apr 14 11:37:40
$BIND Iconic Therapeutics gets $20M in funding http://t.co/8GknFzz587
Prescott Lewis
16 Apr 14 10:40:18
$BIND BIND THERAPEUTICS, INC Files SEC form 8-K, Other Events http://t.co/QEe8y1HBEh
16 Apr 14 10:35:06
$BIND Islet Sciences Announces Positive 12-Week Phase 2 Clinical Results for SGLT2 ... http://t.co/kYUjOAdkxp
Esau Braxton
16 Apr 14 08:07:16
$BIND BIND Therapeutics Prese http://t.co/9hpHZtEsP7
Esau Cooper
16 Apr 14 07:17:59
$BIND BIND THERAPEUTICS, INC Files SEC form 8-K, Other Events http://t.co/8SkfP7T2cO
Financial Alerts
16 Apr 14 06:36:54
$BIND BIND Therapeutics Prese http://t.co/ydx3dgp3th
16 Apr 14 01:55:05
$BIND Karyopharm Announces Initiation of a Phase 1 Study of Decitabine (Dacogen(R ... http://t.co/lrsY5dPjyb
The Amazing Seven
16 Apr 14 01:15:01
$BIND BIND Therapeutics Prese http://t.co/XsUsLJcgRU
15 Apr 14 19:26:41
@zzlangerhans @portefeuillefun I bought the $BIND you sold and than some.
V.S. Schulz
15 Apr 14 19:11:03
RT @zzlangerhans: @portefeuillefun Sold all 1700 $BIND at 8.44 (-$4029), all 1800 $RGLS at 6.35 (-$4248), all 600 $ALNY at 50.14 (-$13302)
Tony Friedman
15 Apr 14 19:10:47
@portefeuillefun Sold all 1700 $BIND at 8.44 (-$4029), all 1800 $RGLS at 6.35 (-$4248), all 600 $ALNY at 50.14 (-$13302)
15 Apr 14 16:03:33
$BIND Karyopharm Announces Initiation of a Phase 1 Study of Decitabine (Dacogen(R ... http://t.co/lrsY5dPjyb
Claudine Salcido
15 Apr 14 14:51:26
$BIND BIND THERAPEUTICS, INC Files SEC form 8-K, Other Events http://t.co/MvQy6G4hCZ
15 Apr 14 14:40:35
$BIND Karyopharm Announces Initiation of a Phase 1 Study of Decitabine (Dacogen(R ... http://t.co/6DY7iOS8Jd
15 Apr 14 13:00:34
$BIND Medicure Comments on Recent Trading Activity http://t.co/0VGQ4WfCt0
15 Apr 14 11:54:16
@dsobek $BIND $APPY look strong too
15 Apr 14 11:52:36
$BIND green!
Bryon Franzen
15 Apr 14 09:42:44
$bind doji star ... double bottom watch ..... will it fail?
Vaughan Lowsley
15 Apr 14 07:53:37
$BIND BIND THERAPEUTICS, INC Files SEC form 8-K, Other Events http://t.co/ntkbrHmtjp
Fausto Tilley
15 Apr 14 07:34:28
$BIND BIND THERAPEUTICS, INC Files SEC form 8-K, Other Events http://t.co/hqjn2JZoCA
Octavio Van
14 Apr 14 18:54:06
$BIND BIND THERAPEUTICS, INC Files SEC form 8-K, Other Events http://t.co/N97NhQzEiY
Boaz Boulstridge
14 Apr 14 11:57:43
$BIND BIND THERAPEUTICS, INC Files SEC form 8-K, Other Events http://t.co/85Pe5bGw8p
14 Apr 14 11:12:34
$BIND Mast Therapeutics (MSTX) Jumps on Positive MST-188 Data http://t.co/7DSOXXTpRu
Dr. Paul DeSantis
14 Apr 14 08:15:05
RT @TomSilver39: $BIND JPM:TP=$30 Promising Signs from Accurin Aurora Kinase B Inhibitor Collaboration at AACR http://t.co/nGC7JUXk8J
Tom Silver
14 Apr 14 08:14:57
$BIND JPM:TP=$30 Promising Signs from Accurin Aurora Kinase B Inhibitor Collaboration at AACR http://t.co/nGC7JUXk8J
Lars Anders
14 Apr 14 07:56:13
$BIND BIND Therapeutics Prese http://t.co/QIxEuXmB9J
14 Apr 14 06:43:47
http://t.co/rruxxSh4Kk $heff: $BIND ..Therapeutics barasertib data positive, says JMP Se... http://t.co/wfqaBbNveW http://t.co/rruxxSh4Kk
14 Apr 14 05:29:25
RT @SheffStation: $BIND Therapeutics barasertib data positive, says JMP Securities. http://t.co/q2JJCMAUpP
14 Apr 14 05:28:06
$BIND Biogen Idec to Present New Clinical Data from Its Robust Neurology Portfolio ... http://t.co/i369krDCxG
14 Apr 14 05:19:04
$BIND Therapeutics barasertib data positive, says JMP Securities. http://t.co/q2JJCMAUpP
North Carter
14 Apr 14 02:19:13
$BIND BIND Therapeutics Prese http://t.co/geixbfm5Rx
13 Apr 14 17:14:04
$BIND Hedge Funds Wield Risky Legal Ploy to Milk Buyouts http://t.co/26HDM3otz6
Crew Gretzky
13 Apr 14 16:41:11
$BIND BIND Therapeutics Prese http://t.co/OqytxWIo2s
Franco Clark
13 Apr 14 06:33:35
$BIND BIND Therapeutics Prese http://t.co/tpcAlO74Wl
Finance Wire
12 Apr 14 16:03:57
$BIND BIND Therapeutics Prese http://t.co/cLo6XG3iHa
Small Cap Updates
12 Apr 14 11:36:57
$BIND BIND Therapeutics Prese http://t.co/9BHMwGPxmV
By  +Follow September 19, 2013 2:04PM



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